Use ESB Toolkit to implement a dynamic self-adapting solution. It enables the implementation of the ESB pattern within BizTalk by maximizing the re-use of services while at the same time maintaining the flexibility to easily change solution. The ESB Toolkit extends the capabilities of supporting a loosely coupled and dynamic messaging architecture.
Here is a good place to start working with the ESB Toolkit by reading the Introduction to the BizTalk ESB Toolkit
If you want a in-depth video on the ESB Toolkit capabilities watch this video